University of California San Francisco

Publications

  1. Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment.
    Ferreira S, Flowers BM, Choi WY, Farina-Morillas M, Gatto A, Bhattacharyya S, Boross G, Hassan G, Mulligan AS, Vogel H, Wood LD, Weaver VM, Winslow MM, Petrov DA, Sherman MH, Choi HY, Hayes DN, Aguirre AJ, Seoane JA, Attardi LD
    Cancer Res. 2026 Jul 02; 86(13):3109-3122.; 
    PubMed
  2. Mechanical regulation of extracellular vesicle activity during tumour progression.
    Parihar K, Liu DA, Hassan G, Issadore DA, Janmey PA, Weaver VM, Guo W, Radhakrishnan R
    Nat Biomed Eng. 2025 Aug; 9(8):1202-1221.; 
    PubMed
  3. Forcing the code: tension modulates signaling to drive morphogenesis and malignancy.
    Narain R, Muncie-Vasic JM, Weaver VM
    Genes Dev. 2025 01 07; 39(1-2):163-181.; 
    PubMed
  4. Free energy calculations for membrane morphological transformations and insights to physical biology and oncology.
    Parihar K, Ko SH, Bradley R, Taylor P, Ramakrishnan N, Baumgart T, Guo W, Weaver VM, Janmey PA, Radhakrishnan R
    Methods Enzymol. 2024; 701:359-386.; 
    PubMed
  5. Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.
    Kersten K, You R, Liang S, Tharp KM, Pollack J, Weaver VM, Krummel MF, Headley MB
    Cell Rep. 2023 06 27; 42(6):112582.; 
    PubMed
  6. Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity.
    Tsai KK, Huang SS, Northey JJ, Liao WY, Hsu CC, Cheng LH, Werner ME, Chuu CP, Chatterjee C, Lakins JN, Weaver VM
    Nat Cancer. 2022 06; 3(6):734-752.; 
    PubMed
  7. Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.
    Hendley AM, Rao AA, Leonhardt L, Ashe S, Smith JA, Giacometti S, Peng XL, Jiang H, Berrios DI, Pawlak M, Li LY, Lee J, Collisson EA, Anderson MS, Fragiadakis GK, Yeh JJ, Ye CJ, Kim GE, Weaver VM, Hebrok M
    Elife. 2021 05 19; 10.; 
    PubMed
  8. Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.
    Maller O, Drain AP, Barrett AS, Borgquist S, Ruffell B, Zakharevich I, Pham TT, Gruosso T, Kuasne H, Lakins JN, Acerbi I, Barnes JM, Nemkov T, Chauhan A, Gruenberg J, Nasir A, Bjarnadottir O, Werb Z, Kabos P, Chen YY, Hwang ES, Park M, Coussens LM, Nelson AC, Hansen KC, Weaver VM
    Nat Mater. 2021 04; 20(4):548-559.; 
    PubMed
  9. Tension in tumour cells keeps metabolism high.
    Ayad NME, Weaver VM
    Nature. 2020 02; 578(7796):517-518.; 
    PubMed
  10. Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.
    Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC
    Elife. 2018 10 09; 7.; 
    PubMed
  11. Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma.
    Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI
    Mol Cancer Res. 2018 05; 16(5):777-790.; 
    PubMed
  12. Cell and tissue mechanics: the new cell biology frontier.
    Weaver VM
    Mol Biol Cell. 2017 07 07; 28(14):1815-1818.; 
    PubMed
  13. From transformation to metastasis: deconstructing the extracellular matrix in breast cancer.
    Kaushik S, Pickup MW, Weaver VM
    Cancer Metastasis Rev. 2016 12; 35(4):655-667.; 
    PubMed
  14. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
    Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM
    Nat Med. 2016 05; 22(5):497-505.; 
    PubMed
  15. STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma.
    Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI
    Cancer Res. 2015 Oct 15; 75(20):4302-11.; 
    PubMed
  16. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate.
    Rubashkin MG, Cassereau L, Bainer R, DuFort CC, Yui Y, Ou G, Paszek MJ, Davidson MW, Chen YY, Weaver VM
    Cancer Res. 2014 Sep 01; 74(17):4597-611.; 
    PubMed
  17. Cell biology. Strength under tension.
    Bainer R, Weaver V
    Science. 2013 Aug 30; 341(6149):965-6.; 
    PubMed
  18. Scanning angle interference microscopy reveals cell dynamics at the nanoscale.
    Paszek MJ, DuFort CC, Rubashkin MG, Davidson MW, Thorn KS, Liphardt JT, Weaver VM
    Nat Methods. 2012 Jul 01; 9(8):825-7.; 
    PubMed
  19. Balancing forces: architectural control of mechanotransduction.
    DuFort CC, Paszek MJ, Weaver VM
    Nat Rev Mol Cell Biol. 2011 May; 12(5):308-19.; 
    PubMed
  20. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.
    Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM
    J Clin Invest. 2010 May; 120(5):1535-50.; 
    PubMed
  21. CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.
    Vasilatos SN, Broadwater G, Barry WT, Baker JC, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, Ibarra-Drendall C, Ostrander JH, D'Amato NC, Zalles C, Jirtle R, Weaver VM, Seewaldt VL
    Cancer Epidemiol Biomarkers Prev. 2009 Mar; 18(3):901-14.; 
    PubMed
  22. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.
    Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM
    J Cell Sci. 2007 Oct 15; 120(Pt 20):3700-12.; 
    PubMed
  23. Tensional homeostasis and the malignant phenotype.
    Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM
    Cancer Cell. 2005 Sep; 8(3):241-54.; 
    PubMed
  24. Associations of lead biomarkers with renal function in Korean lead workers.
    Weaver VM, Lee BK, Ahn KD, Lee GS, Todd AC, Stewart WF, Wen J, Simon DJ, Parsons PJ, Schwartz BS
    Occup Environ Med. 2003 Aug; 60(8):551-62.; 
    PubMed
  25. E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture.
    Spancake KM, Anderson CB, Weaver VM, Matsunami N, Bissell MJ, White RL
    Cancer Res. 1999 Dec 15; 59(24):6042-5.; 
    PubMed
  26. Differentiation and cancer in the mammary gland: shedding light on an old dichotomy.
    Petersen OW, Rønnov-Jessen L, Weaver VM, Bissell MJ
    Adv Cancer Res. 1998; 75:135-61.; 
    PubMed
  27. Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation.
    Lelièvre S, Weaver VM, Bissell MJ
    Recent Prog Horm Res. 1996; 51:417-32.; 
    PubMed
  28. Tissue tension fosters macrophage-driven lipid peroxidation-induced DNA damage.
    Hayward MK, Northey JJ, Opazo-Mellado V, Stashko C, Maller O, Ironside AJ, Que X, Lakins JN, Hwang ES, Witztum JL, Gonzalez H, Weaver VM
    Cancer Cell. 2026 Jun 08; 44(6):1255-1269.e9.; 
    PubMed
  29. Tissue mechanics in tumor heterogeneity and aggression.
    Finger AM, Hendley AM, Figueroa D, Gonzalez H, Weaver VM
    Trends Cancer. 2025 Aug; 11(8):806-824.; 
    PubMed
  30. Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment.
    Tharp KM, Kersten K, Maller O, Timblin GA, Stashko C, Canale FP, Menjivar RE, Hayward MK, Berestjuk I, Ten Hoeve J, Samad B, Ironside AJ, di Magliano MP, Muir A, Geiger R, Combes AJ, Weaver VM
    Nat Cancer. 2024 Jul; 5(7):1045-1062.; 
    PubMed
  31. Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk.
    Northey JJ, Hayward MK, Yui Y, Stashko C, Kai F, Mouw JK, Thakar D, Lakins JN, Ironside AJ, Samson S, Mukhtar RA, Hwang ES, Weaver VM
    Cell Stem Cell. 2024 01 04; 31(1):106-126.e13.; 
    PubMed
  32. Extracellular Matrix Glycation and Crosslinking in Mammary Tumor Progression.
    Northey JJ, Weaver VM
    Methods Mol Biol. 2023; 2614:247-260.; 
    PubMed
  33. Mechanobiology: forcing the second act.
    Weaver VM
    Mol Biol Cell. 2021 08 19; 32(18):1611-1613.; 
    PubMed
  34. Towards enhanced understanding of idiopathic ketotic hypoglycemia: a literature review and introduction of the patient organization, Ketotic Hypoglycemia International.
    Drachmann D, Hoffmann E, Carrigg A, Davis-Yates B, Weaver V, Thornton P, Weinstein DA, Petersen JS, Shah P, Christesen HT
    Orphanet J Rare Dis. 2021 04 13; 16(1):173.; 
    PubMed
  35. Zena Werb (1945-2020): Mourning the loss of a tissue microenvironment icon.
    Weaver VM, Bissell MJ
    Proc Natl Acad Sci U S A. 2020 11 10; 117(45):27759-27760.; 
    PubMed
  36. Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics.
    Muncie JM, Falcón-Banchs R, Lakins JN, Sohn LL, Weaver VM
    J Vis Exp. 2019 09 28; (151).; 
    PubMed
  37. Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells.
    Sampayo RG, Toscani AM, Rubashkin MG, Thi K, Masullo LA, Violi IL, Lakins JN, Cáceres A, Hines WC, Coluccio Leskow F, Stefani FD, Chialvo DR, Bissell MJ, Weaver VM, Simian M
    J Cell Biol. 2018 08 06; 217(8):2777-2798.; 
    PubMed
  38. A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression.
    Woods EC, Kai F, Barnes JM, Pedram K, Pickup MW, Hollander MJ, Weaver VM, Bertozzi CR
    Elife. 2017 12 21; 6.; 
    PubMed
  39. Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy.
    Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver VM, Hwang DG, Chan MF
    PLoS One. 2017; 12(4):e0175112.; 
    PubMed
  40. Cellular adaptation to biomechanical stress across length scales in tissue homeostasis and disease.
    Gilbert PM, Weaver VM
    Semin Cell Dev Biol. 2017 07; 67:141-152.; 
    PubMed
  41. Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha.
    Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT
    Hepatology. 2016 07; 64(1):261-75.; 
    PubMed
  42. Tumor mechanics and metabolic dysfunction.
    Tung JC, Barnes JM, Desai SR, Sistrunk C, Conklin MW, Schedin P, Eliceiri KW, Keely PJ, Seewaldt VL, Weaver VM
    Free Radic Biol Med. 2015 Feb; 79:269-80.; 
    PubMed
  43. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.
    Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R
    Cancer Cell. 2014 Jun 16; 25(6):719-34.; 
    PubMed
  44. Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.
    Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM
    Oncogene. 2014 May 08; 33(19):2441-53.; 
    PubMed
  45. Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels.
    Lakins JN, Chin AR, Weaver VM
    Methods Mol Biol. 2012; 916:317-50.; 
    PubMed
  46. The extracellular matrix at a glance.
    Frantz C, Stewart KM, Weaver VM
    J Cell Sci. 2010 Dec 15; 123(Pt 24):4195-200.; 
    PubMed
  47. Matrix crosslinking forces tumor progression by enhancing integrin signaling.
    Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM
    Cell. 2009 Nov 25; 139(5):891-906.; 
    PubMed
  48. Three-dimensional context regulation of metastasis.
    Erler JT, Weaver VM
    Clin Exp Metastasis. 2009; 26(1):35-49.; 
    PubMed
  49. Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis.
    Johnson KR, Leight JL, Weaver VM
    Methods Cell Biol. 2007; 83:547-83.; 
    PubMed
  50. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.
    Yeung T, Georges PC, Flanagan LA, Marg B, Ortiz M, Funaki M, Zahir N, Ming W, Weaver V, Janmey PA
    Cell Motil Cytoskeleton. 2005 Jan; 60(1):24-34.; 
    PubMed
  51. The organizing principle: microenvironmental influences in the normal and malignant breast.
    Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW
    Differentiation. 2002 Dec; 70(9-10):537-46.; 
    PubMed
  52. Tissue structure, nuclear organization, and gene expression in normal and malignant breast.
    Bissell MJ, Weaver VM, Lelièvre SA, Wang F, Petersen OW, Schmeichel KL
    Cancer Res. 1999 Apr 01; 59(7 Suppl):1757-1763s; discussion 1763s-1764s.; 
    PubMed
  53. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies.
    Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ
    J Cell Biol. 1997 Apr 07; 137(1):231-45.; 
    PubMed
  54. The development of a functionally relevant cell culture model of progressive human breast cancer.
    Weaver VM, Howlett AR, Langton-Webster B, Petersen OW, Bissell MJ
    Semin Cancer Biol. 1995 Jun; 6(3):175-84.; 
    PubMed
  55. The microenvironment dictates glyco-immune surveillance via HSF1-mediated metabolism.
    Tharp KM, Park S, Timblin GA, Richards AL, Berg JA, Twells NM, Riley NM, Alvarez K, Lee A, Peltan EL, Shon DJ, Stevenson E, Tsui K, Palomba F, Lefebvre AEYT, Soens RW, Thangaraj JL, Ayad NME, Rhodenhiser JA, Ten Hoeve J, Healy K, Digman M, Dillin A, Krogan NJ, Bertozzi CR, Kaufman DS, Sinha S, Swaney DL, Mahal LK, Cantor JR, Paszek MJ, Weaver VM
    Sci Adv. 2026 Aug 07; 12(32):eaeb1136.; 
    PubMed
  56. Axonal injury is a targetable driver of glioblastoma progression.
    Clements M, Tang W, Florjanic Baronik Z, Simpson Ragdale H, Oria R, Volteras D, White IJ, Beattie G, Uddin I, Lenn T, Lindsay R, Castro Devesa S, Karamched SR, Lythgoe MF, Shahrezaei V, Weaver VM, Sugisawa R, Roncaroli F, Marguerat S, Hill CS, Parrinello S
    Nature. 2025 10; 646(8084):452-461.; 
    PubMed
  57. Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling.
    Nakagawa R, Beardsley A, Durney S, Hayward MK, Subramanyam V, Meyer NP, Wismer H, Goodarzi H, Weaver VM, Van de Mark D, Goga A
    bioRxiv. 2025 Jan 31.; 
    PubMed
  58. Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies.
    Goyette MA, Stevens LE, DePinho CR, Seehawer M, Nishida J, Li Z, Wilde CM, Li R, Qiu X, Pyke AL, Zhao S, Lim K, Tender GS, Northey JJ, Riley NM, Long HW, Bertozzi CR, Weaver VM, Polyak K
    Proc Natl Acad Sci U S A. 2024 May 14; 121(20):e2322688121.; 
    PubMed
  59. Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.
    Ayad NME, Lakins JN, Ghagre A, Ehrlicher AJ, Weaver VM
    bioRxiv. 2023 Jul 15.; 
    PubMed
  60. Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer.
    Bell ES, Shah P, Zuela-Sopilniak N, Kim D, Varlet AA, Morival JLP, McGregor AL, Isermann P, Davidson PM, Elacqua JJ, Lakins JN, Vahdat L, Weaver VM, Smolka MB, Span PN, Lammerding J
    Oncogene. 2022 09; 41(36):4211-4230.; 
    PubMed
  61. EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts.
    Kindberg AA, Srivastava V, Muncie JM, Weaver VM, Gartner ZJ, Bush JO
    J Cell Biol. 2021 06 07; 220(6).; 
    PubMed
  62. Derivation of a nuclear heterogeneity image index to grade DCIS.
    Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC, Shelley Hwang E, Weaver VM
    Comput Struct Biotechnol J. 2020; 18:4063-4070.; 
    PubMed
  63. Zena Werb 1945-2020.
    Egeblad M, Coussens LM, Weaver VM
    Nat Cancer. 2020 08; 1(8):753-754.; 
    PubMed
  64. Tissue mechanics, an important regulator of development and disease.
    Ayad NME, Kaushik S, Weaver VM
    Philos Trans R Soc Lond B Biol Sci. 2019 08 19; 374(1779):20180215.; 
    PubMed
  65. New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.
    Samson S, Northey JJ, Plaks V, Baas C, Dean I, LaBarge MA, Goga A, Van't Veer LJ, Weaver VM
    Trends Cancer. 2018 04; 4(4):260-264.; 
    PubMed
  66. Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells.
    Pickup MW, Owens P, Gorska AE, Chytil A, Ye F, Shi C, Weaver VM, Kalluri R, Moses HL, Novitskiy SV
    Cancer Immunol Res. 2017 09; 5(9):718-729.; 
    PubMed
  67. Force-dependent breaching of the basement membrane.
    Chang TT, Thakar D, Weaver VM
    Matrix Biol. 2017 01; 57-58:178-189.; 
    PubMed
  68. Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer.
    Przybyla L, Muncie JM, Weaver VM
    Annu Rev Cell Dev Biol. 2016 10 06; 32:527-554.; 
    PubMed
  69. Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors.
    Lin CH, Pelissier FA, Zhang H, Lakins J, Weaver VM, Park C, LaBarge MA
    Mol Biol Cell. 2015 Nov 05; 26(22):3946-53.; 
    PubMed
  70. Extracellular matrix assembly: a multiscale deconstruction.
    Mouw JK, Ou G, Weaver VM
    Nat Rev Mol Cell Biol. 2014 Dec; 15(12):771-85.; 
    PubMed
  71. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.
    Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM
    Nat Med. 2014 Apr; 20(4):360-7.; 
    PubMed
  72. A physical sciences network characterization of non-tumorigenic and metastatic cells.
    Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH
    Sci Rep. 2013; 3:1449.; 
    PubMed
  73. Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
    Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF
    Cancer Cell. 2011 Jun 14; 19(6):776-91.; 
    PubMed
  74. Dynamic interplay between the collagen scaffold and tumor evolution.
    Egeblad M, Rasch MG, Weaver VM
    Curr Opin Cell Biol. 2010 Oct; 22(5):697-706.; 
    PubMed
  75. The tissue diagnostic instrument.
    Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Diez-Perez A, Alliston T, Weaver V, Lotz J
    Rev Sci Instrum. 2009 May; 80(5):054303.; 
    PubMed
  76. Integrin-mediated signalling through the MAP-kinase pathway.
    Yee KL, Weaver VM, Hammer DA
    IET Syst Biol. 2008 Jan; 2(1):8-15.; 
    PubMed
  77. Forcing the third dimension.
    Boudreau N, Weaver V
    Cell. 2006 May 05; 125(3):429-31.; 
    PubMed
  78. Death in the third dimension: apoptosis regulation and tissue architecture.
    Zahir N, Weaver VM
    Curr Opin Genet Dev. 2004 Feb; 14(1):71-80.; 
    PubMed
  79. Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation.
    Chrenek MA, Wong P, Weaver VM
    Breast Cancer Res. 2001; 3(4):224-9.; 
    PubMed
  80. Approaches to environmental exposure assessment in children.
    Weaver VM, Buckley TJ, Groopman JD
    Environ Health Perspect. 1998 Jun; 106 Suppl 3:827-32.; 
    PubMed
  81. Benzene exposure, assessed by urinary trans,trans-muconic acid, in urban children with elevated blood lead levels.
    Weaver VM, Davoli CT, Heller PJ, Fitzwilliam A, Peters HL, Sunyer J, Murphy SE, Goldstein GW, Groopman JD
    Environ Health Perspect. 1996 Mar; 104(3):318-23.; 
    PubMed
  82. Generation of Polyacrylamide and Silicone Extracellular Matrix Substrates with Defined Stiffness for Cell Biology Applications.
    Almsoud A, Nyaupane U, Jain K, Hassan G, Lakins JN, Weaver VM, Kai F
    J Vis Exp. 2026 Jun 26; (232).; 
    PubMed
  83. A STAT3/integrin axis accelerates pancreatic cancer initiation and progression.
    Campos AD, Shepard RM, Ortega Z, Heumann I, Wilke AE, Nam A, Cable C, Kouhmareh K, Klemke R, Mattson NM, Ideker T, De Arruda Saldanha C, Heinz S, Weaver V, Von Schalscha T, Wettersten HI, Weis SM, Cheresh DA
    Cell Rep. 2025 Aug 26; 44(8):116010.; 
    PubMed
  84. Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option.
    Uroz M, Stoddard AE, Sutherland BP, Courbot O, Oria R, Li L, Ravasio CR, Ngo MT, Yang J, Tefft JB, Eyckmans J, Han X, Elosegui-Artola A, Weaver VM, Chen CS
    Nat Cell Biol. 2024 Dec; 26(12):2144-2153.; 
    PubMed
  85. Assessing Heterogeneity in the N-Telopeptides of Type I Collagen by Mass Spectrometry.
    Darula Z, McCabe MC, Barrett A, Schmitt LR, Maslanka MD, Saviola AJ, Orgel J, Burlingame A, Staab-Weijnitz CA, Stenmark K, Weaver V, Chalkley RJ, Hansen KC
    bioRxiv. 2024 Mar 31.; 
    PubMed
  86. Stiff matrix induces exosome secretion to promote tumour growth.
    Wu B, Liu DA, Guan L, Myint PK, Chin L, Dang H, Xu Y, Ren J, Li T, Yu Z, Jabban S, Mills GB, Nukpezah J, Chen YH, Furth EE, Gimotty PA, Wells RG, Weaver VM, Radhakrishnan R, Wang XW, Guo W
    Nat Cell Biol. 2023 03; 25(3):415-424.; 
    PubMed
  87. Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression.
    Metcalf KJ, Hayward MK, Berens E, Ironside AJ, Stashko C, Hwang ES, Weaver VM
    Matrix Biol Plus. 2022 Jun; 14:100105.; 
    PubMed
  88. Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer.
    Drain AP, Zahir N, Northey JJ, Zhang H, Huang PJ, Maller O, Lakins JN, Yu X, Leight JL, Alston-Mills BP, Hwang ES, Chen YY, Park CC, Weaver VM
    J Exp Med. 2021 05 03; 218(5).; 
    PubMed
  89. Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells.
    Muncie JM, Ayad NME, Lakins JN, Xue X, Fu J, Weaver VM
    Dev Cell. 2020 12 21; 55(6):679-694.e11.; 
    PubMed
  90. A framework for advancing our understanding of cancer-associated fibroblasts.
    Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z
    Nat Rev Cancer. 2020 03; 20(3):174-186.; 
    PubMed
  91. A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.
    Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM
    Nat Cell Biol. 2018 10; 20(10):1203-1214.; 
    PubMed
  92. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers.
    Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z
    Genes Dev. 2018 02 01; 32(3-4):244-257.; 
    PubMed
  93. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.
    Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF
    Science. 2017 05 12; 356(6338).; 
    PubMed
  94. Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells.
    Chan TS, Hsu CC, Pai VC, Liao WY, Huang SS, Tan KT, Yen CJ, Hsu SC, Chen WY, Shan YS, Li CR, Lee MT, Jiang KY, Chu JM, Lien GS, Weaver VM, Tsai KK
    J Exp Med. 2016 12 12; 213(13):2967-2988.; 
    PubMed
  95. Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.
    Kai F, Laklai H, Weaver VM
    Trends Cell Biol. 2016 07; 26(7):486-497.; 
    PubMed
  96. Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.
    Acerbi I, Cassereau L, Dean I, Shi Q, Au A, Park C, Chen YY, Liphardt J, Hwang ES, Weaver VM
    Integr Biol (Camb). 2015 Oct; 7(10):1120-34.; 
    PubMed
  97. Multicellular architecture of malignant breast epithelia influences mechanics.
    Venugopalan G, Camarillo DB, Webster KD, Reber CD, Sethian JA, Weaver VM, Fletcher DA, El-Samad H, Rycroft CH
    PLoS One. 2014; 9(8):e101955.; 
    PubMed
  98. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas.
    Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL
    Cancer Res. 2013 Sep 01; 73(17):5336-46.; 
    PubMed
  99. Morphogenesis: Laying down the tracks.
    Cassereau L, DuFort CC, Weaver VM
    Nat Mater. 2012 May 22; 11(6):490-2.; 
    PubMed
  100. Tumor microenvironment and progression.
    Dvorak HF, Weaver VM, Tlsty TD, Bergers G
    J Surg Oncol. 2011 May 01; 103(6):468-74.; 
    PubMed
  101. Biophysics. Enforcing order on signaling.
    Paszek M, Weaver V
    Science. 2010 Mar 12; 327(5971):1335-6.; 
    PubMed
  102. A tense situation: forcing tumour progression.
    Butcher DT, Alliston T, Weaver VM
    Nat Rev Cancer. 2009 Feb; 9(2):108-22.; 
    PubMed
  103. G'rab'bing the microenvironment for invasion.
    Weaver V, Werb Z
    Dev Cell. 2007 Oct; 13(4):462-3.; 
    PubMed
  104. Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.
    Yang C, Liu Y, Leskow FC, Weaver VM, Kazanietz MG
    J Biol Chem. 2005 Jul 01; 280(26):24363-70.; 
    PubMed
  105. Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin.
    Russell AJ, Fincher EF, Millman L, Smith R, Vela V, Waterman EA, Dey CN, Guide S, Weaver VM, Marinkovich MP
    J Cell Sci. 2003 Sep 01; 116(Pt 17):3543-56.; 
    PubMed
  106. Constitutive expression of Heregulin induces apoptosis in an erbB-2 overexpressing breast cancer cell line SKBr-3.
    Guerra-Vladusic FK, Scott G, Weaver V, Vladusic EA, Tsai MS, Benz CC, Lupu R
    Int J Oncol. 1999 Nov; 15(5):883-92.; 
    PubMed
  107. Chemical hazards in health care workers.
    Weaver VM
    Occup Med. 1997 Oct-Dec; 12(4):655-67.; 
    PubMed
  108. The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay.
    Weaver VM, Fischer AH, Peterson OW, Bissell MJ
    Biochem Cell Biol. 1996; 74(6):833-51.; 
    PubMed
  109. The Interplay Between Circadian Clocks and the Tumour Microenvironment in Breast Cancer.
    Finger AM, Ector C, Weaver VM
    Cancers (Basel). 2026 Mar 12; 18(6).; 
    PubMed
  110. NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer.
    Ticha P, Northey JJ, Kersten K, Velozo HG, Ironside AJ, Zidek M, Drain A, Lakins JN, Chen YY, Tsai KK, Weaver VM
    bioRxiv. 2025 Mar 12.; 
    PubMed
  111. Patterning and folding of intestinal villi by active mesenchymal dewetting.
    Huycke TR, Häkkinen TJ, Miyazaki H, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, Oria R, Weaver VM, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ
    Cell. 2024 Jun 06; 187(12):3072-3089.e20.; 
    PubMed
  112. The microenvironment dictates glycocalyx construction and immune surveillance.
    Tharp KM, Park S, Timblin GA, Richards AL, Berg JA, Twells NM, Riley NM, Peltan EL, Shon DJ, Stevenson E, Tsui K, Palomba F, Lefebvre AEYT, Soens RW, Ayad NME, Hoeve-Scott JT, Healy K, Digman M, Dillin A, Bertozzi CR, Swaney DL, Mahal LK, Cantor JR, Paszek MJ, Weaver VM
    Res Sq. 2023 Aug 16.; 
    PubMed
  113. Novel cryo-tomography workflow reveals nanometer-scale responses of epithelial cells to matrix stiffness and dimensionality.
    Gaietta G, Kai F, Swift MF, Weaver VM, Volkmann N, Hanein D
    Mol Biol Cell. 2022 12 01; 33(14):br28.; 
    PubMed
  114. Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis.
    Rudnick JA, Monkkonen T, Mar FA, Barnes JM, Starobinets H, Goldsmith J, Roy S, Bustamante Eguiguren S, Weaver VM, Debnath J
    Genes Dev. 2021 07 01; 35(13-14):963-975.; 
    PubMed
  115. Leveraging microenvironmental synthetic lethalities to treat cancer.
    Metcalf KJ, Alazzeh A, Werb Z, Weaver VM
    J Clin Invest. 2021 03 15; 131(6).; 
    PubMed
  116. Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix.
    Jiang H, Torphy RJ, Steiger K, Hongo H, Ritchie AJ, Kriegsmann M, Horst D, Umetsu SE, Joseph NM, McGregor K, Pishvaian MJ, Blais EM, Lu B, Li M, Hollingsworth M, Stashko C, Volmar K, Yeh JJ, Weaver VM, Wang ZJ, Tempero MA, Weichert W, Collisson EA
    J Clin Invest. 2020 09 01; 130(9):4704-4709.; 
    PubMed
  117. Controlled modelling of human epiblast and amnion development using stem cells.
    Zheng Y, Xue X, Shao Y, Wang S, Esfahani SN, Li Z, Muncie JM, Lakins JN, Weaver VM, Gumucio DL, Fu J
    Nature. 2019 09; 573(7774):421-425.; 
    PubMed
  118. Compartment resolved proteomics reveals a dynamic matrisome in a biomechanically driven model of pancreatic ductal adenocarcinoma.
    Barrett AS, Maller O, Pickup MW, Weaver VM, Hansen KC
    J Immunol Regen Med. 2018 Mar; 1:67-75.; 
    PubMed
  119. Tissue Force Programs Cell Fate and Tumor Aggression.
    Northey JJ, Przybyla L, Weaver VM
    Cancer Discov. 2017 11; 7(11):1224-1237.; 
    PubMed
  120. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.
    Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM
    Mol Biol Cell. 2017 Jun 01; 28(11):1467-1488.; 
    PubMed
  121. Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.
    Przybyla L, Lakins JN, Weaver VM
    Cell Stem Cell. 2016 10 06; 19(4):462-475.; 
    PubMed
  122. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
    Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R
    Cancer Cell. 2015 Dec 14; 28(6):831-833.; 
    PubMed
  123. A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype.
    Cassereau L, Miroshnikova YA, Ou G, Lakins J, Weaver VM
    J Biotechnol. 2015 Jan 10; 193:66-9.; 
    PubMed
  124. Understanding tissue context influences on intratumour heterogeneity.
    Michor F, Weaver VM
    Nat Cell Biol. 2014 Apr; 16(4):301-2.; 
    PubMed
  125. YAP forces fibroblasts to feel the tension.
    Maller O, DuFort CC, Weaver VM
    Nat Cell Biol. 2013 Jun; 15(6):570-2.; 
    PubMed
  126. Extracellular matrix degradation and remodeling in development and disease.
    Lu P, Takai K, Weaver VM, Werb Z
    Cold Spring Harb Perspect Biol. 2011 Dec 01; 3(12).; 
    PubMed
  127. Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis.
    Brown XQ, Bartolak-Suki E, Williams C, Walker ML, Weaver VM, Wong JY
    J Cell Physiol. 2010 Oct; 225(1):115-22.; 
    PubMed
  128. Mechanics, malignancy, and metastasis: the force journey of a tumor cell.
    Kumar S, Weaver VM
    Cancer Metastasis Rev. 2009 Jun; 28(1-2):113-27.; 
    PubMed
  129. A human breast cell model of preinvasive to invasive transition.
    Rizki A, Weaver VM, Lee SY, Rozenberg GI, Chin K, Myers CA, Bascom JL, Mott JD, Semeiks JR, Grate LR, Mian IS, Borowsky AD, Jensen RA, Idowu MO, Chen F, Chen DJ, Petersen OW, Gray JW, Bissell MJ
    Cancer Res. 2008 Mar 01; 68(5):1378-87.; 
    PubMed
  130. Lead-related nephrotoxicity: a review of the epidemiologic evidence.
    Ekong EB, Jaar BG, Weaver VM
    Kidney Int. 2006 Dec; 70(12):2074-84.; 
    PubMed
  131. The tension mounts: mechanics meets morphogenesis and malignancy.
    Paszek MJ, Weaver VM
    J Mammary Gland Biol Neoplasia. 2004 Oct; 9(4):325-42.; 
    PubMed
  132. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium.
    Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ
    Cancer Cell. 2002 Sep; 2(3):205-16.; 
    PubMed
  133. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology.
    Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ
    Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14821-6.; 
    PubMed
  134. Extracellular matrix: the central regulator of cell and tissue homeostasis.
    Weaver VM, Roskelley CD
    Trends Cell Biol. 1997 Jan; 7(1):40-2.; 
    PubMed
  135. Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes.
    Weaver VM, Lach B, Walker PR, Sikorska M
    Biochem Cell Biol. 1993 Sep-Oct; 71(9-10):488-500.; 
    PubMed
  136. Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.
    Ayad NME, Almsoud A, Lakins JN, Ghagre A, Ehrlicher AJ, Klein OD, Kai F, Weaver VM
    Dev Cell. 2026 Jul 13.; 
    PubMed
  137. Pancreatic Cancer Progression Involves Increased Lysyl Oxidase-Mediated Collagen Cross-Links as Part of the Desmoplastic Reaction.
    Barrett A, Maslanka MD, Darula Z, McCabe MC, Saviola AJ, Schmitt LR, Weaver V, Pitts TM, Messersmith WA, Hansen KC
    Biochemistry. 2025 08 19; 64(16):3515-3525.; 
    PubMed
  138. Tension-induced organelle stress: an emerging target in fibrosis.
    Kai F, Leidal AM, Weaver VM
    Trends Pharmacol Sci. 2025 02; 46(2):117-131.; 
    PubMed
  139. Asymmetric crowders and membrane morphology at the nexus of intracellular trafficking and oncology.
    Parihar K, Ko SB, Bradley RP, Taylor P, Ramakrishnan N, Baumgart T, Guo W, Weaver VM, Janmey PA, Radhakrishnan R
    Mechanobiol Med. 2024 Sep; 2(3).; 
    PubMed
  140. A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.
    Stashko C, Hayward MK, Northey JJ, Pearson N, Ironside AJ, Lakins JN, Oria R, Goyette MA, Mayo L, Russnes HG, Hwang ES, Kutys ML, Polyak K, Weaver VM
    Nat Commun. 2023 06 15; 14(1):3561.; 
    PubMed
  141. ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.
    Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R, Weaver VM
    EMBO J. 2022 09 01; 41(17):e109205.; 
    PubMed
  142. Adhesion-mediated mechanosignaling forces mitohormesis.
    Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saijo K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM
    Cell Metab. 2021 07 06; 33(7):1322-1341.e13.; 
    PubMed
  143. Proteoglycans as Mediators of Cancer Tissue Mechanics.
    Barkovskaya A, Buffone A, Žídek M, Weaver VM
    Front Cell Dev Biol. 2020; 8:569377.; 
    PubMed
  144. Fibrosis and cancer: A strained relationship.
    Piersma B, Hayward MK, Weaver VM
    Biochim Biophys Acta Rev Cancer. 2020 04; 1873(2):188356.; 
    PubMed
  145. The Extracellular Matrix Modulates the Metastatic Journey.
    Kai F, Drain AP, Weaver VM
    Dev Cell. 2019 05 06; 49(3):332-346.; 
    PubMed
  146. Feeling Stress: The Mechanics of Cancer Progression and Aggression.
    Northcott JM, Dean IS, Mouw JK, Weaver VM
    Front Cell Dev Biol. 2018; 6:17.; 
    PubMed
  147. Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.
    Salvador F, Martin A, López-Menéndez C, Moreno-Bueno G, Santos V, Vázquez-Naharro A, Santamaria PG, Morales S, Dubus PR, Muinelo-Romay L, López-López R, Tung JC, Weaver VM, Portillo F, Cano A
    Cancer Res. 2017 11 01; 77(21):5846-5859.; 
    PubMed
  148. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer.
    Takai K, Le A, Weaver VM, Werb Z
    Oncotarget. 2016 Dec 13; 7(50):82889-82901.; 
    PubMed
  149. Site-Specific Modulation of Charge Controls the Structure and Stimulus Responsiveness of Intrinsically Disordered Peptide Brushes.
    Bhagawati M, Rubashkin MG, Lee JP, Ananthanarayanan B, Weaver VM, Kumar S
    Langmuir. 2016 06 14; 32(23):5990-6.; 
    PubMed
  150. Monitoring developmental force distributions in reconstituted embryonic epithelia.
    Przybyla L, Lakins JN, Sunyer R, Trepat X, Weaver VM
    Methods. 2016 Feb 01; 94:101-13.; 
    PubMed
  151. The microenvironment matters.
    Weaver VM
    Mol Biol Cell. 2014 Nov 01; 25(21):3254-8.; 
    PubMed
  152. Rapid disorganization of mechanically interacting systems of mammary acini.
    Shi Q, Ghosh RP, Engelke H, Rycroft CH, Cassereau L, Sethian JA, Weaver VM, Liphardt JT
    Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):658-63.; 
    PubMed
  153. Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer.
    Li CR, Su JJ, Wang WY, Lee MT, Wang TY, Jiang KY, Li CF, Hsu JM, Chen CK, Chen M, Jiang SS, Weaver VM, Tsai KK
    Am J Pathol. 2013 Feb; 182(2):363-74.; 
    PubMed
  154. Valerie Weaver: overcoming cancer's stiff resistance. Interview by Caitlin Sedwick.
    Weaver V
    J Cell Biol. 2011 May 30; 193(5):802-3.; 
    PubMed
  155. SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.
    Cohet N, Stewart KM, Mudhasani R, Asirvatham AJ, Mallappa C, Imbalzano KM, Weaver VM, Imbalzano AN, Nickerson JA
    J Cell Physiol. 2010 Jun; 223(3):667-78.; 
    PubMed
  156. Multiscale modeling of form and function.
    Engler AJ, Humbert PO, Wehrle-Haller B, Weaver VM
    Science. 2009 Apr 10; 324(5924):208-12.; 
    PubMed
  157. Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures.
    Hebner C, Weaver VM, Debnath J
    Annu Rev Pathol. 2008; 3:313-39.; 
    PubMed
  158. Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard.
    Yan Y, Weaver VM, Blair IA
    J Proteome Res. 2005 Nov-Dec; 4(6):2007-14.; 
    PubMed
  159. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.
    Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM
    J Cell Biol. 2003 Dec 22; 163(6):1397-407.; 
    PubMed
  160. Lack of specificity of trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foods.
    Weaver VM, Buckley T, Groopman JD
    Cancer Epidemiol Biomarkers Prev. 2000 Jul; 9(7):749-55.; 
    PubMed
  161. Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype.
    Schmeichel KL, Weaver VM, Bissell MJ
    J Mammary Gland Biol Neoplasia. 1998 Apr; 3(2):201-13.; 
    PubMed
  162. Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes.
    Weaver VM, Carson CE, Walker PR, Chaly N, Lach B, Raymond Y, Brown DL, Sikorska M
    J Cell Sci. 1996 Jan; 109 ( Pt 1):45-56.; 
    PubMed
  163. NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer.
    Ticha P, Northey JJ, Narain R, Sharma S, Lakins JN, Gonzalez H, Kersten K, Ironside AJ, Drain AP, Zidek M, Tsai KK, Chen YY, Shenderov E, Weaver VM
    Nat Commun. 2026 May 05; 17(1).; 
    PubMed
  164. Proteomic characterization of type I collagen N-terminal crosslinked peptides.
    Darula Z, McCabe MC, Barrett A, Schmitt LR, Maslanka MD, Saviola AJ, Orgel J, Burlingame A, Staab-Weijnitz CA, Stenmark K, Weaver V, Chalkley RJ, Hansen KC
    Matrix Biol Plus. 2025 Aug; 27:100179.; 
    PubMed
  165. nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer.
    Hendley AM, Ashe S, Urano A, Ng M, Phu TA, Peng XL, Luan C, Finger AM, Jang GH, Kerper NR, Berrios DI, Jin D, Lee J, Riahi IR, Gbenedio OM, Chung C, Roose JP, Yeh JJ, Gallinger S, Biankin AV, O'Kane GM, Ntranos V, Chang DK, Dawson DW, Kim GE, Weaver VM, Raffai RL, Hebrok M
    bioRxiv. 2024 Sep 25.; 
    PubMed
  166. Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth.
    Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF
    Cancer Cell. 2024 Feb 12; 42(2):317.; 
    PubMed
  167. Programming the Self-Organization of Endothelial Cells into Perfusable Microvasculature.
    Cabral KA, Srivastava V, Graham AJ, Coyle MC, Stashko C, Weaver V, Gartner ZJ
    Tissue Eng Part A. 2023 02; 29(3-4):80-92.; 
    PubMed
  168. NCI's publication affiliation conundrum: Reframing innovation to incentivize an equitable path for advocate representation.
    Samson S, Northey JJ, Acerbi I, Goga A, Flink CL, Weaver VM, LaBarge MA
    Transl Oncol. 2022 Feb; 16:101325.; 
    PubMed
  169. Improving DCIS diagnosis and predictive outcome by applying artificial intelligence.
    Hayward MK, Weaver VM
    Biochim Biophys Acta Rev Cancer. 2021 08; 1876(1):188555.; 
    PubMed
  170. Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.
    Northey JJ, Barrett AS, Acerbi I, Hayward MK, Talamantes S, Dean IS, Mouw JK, Ponik SM, Lakins JN, Huang PJ, Wu J, Shi Q, Samson S, Keely PJ, Mukhtar RA, Liphardt JT, Shepherd JA, Hwang ES, Chen YY, Hansen KC, Littlepage LE, Weaver VM
    J Clin Invest. 2020 11 02; 130(11):5721-5737.; 
    PubMed
  171. Don't sugarcoat it: How glycocalyx composition influences cancer progression.
    Buffone A, Weaver VM
    J Cell Biol. 2020 01 06; 219(1).; 
    PubMed
  172. Modeling Tissue Polarity in Context.
    Tharp KM, Weaver VM
    J Mol Biol. 2018 09 28; 430(19):3613-3628.; 
    PubMed
  173. Excess area dependent scaling behavior of nano-sized membrane tethers.
    Ramakrishnan N, Sreeja KK, Roychoudhury A, Eckmann DM, Ayyaswamy PS, Baumgart T, Pucadyil T, Patil S, Weaver VM, Radhakrishnan R
    Phys Biol. 2018 01 11; 15(2):026002.; 
    PubMed
  174. Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis.
    Oudin MJ, Weaver VM
    Cold Spring Harb Symp Quant Biol. 2016; 81:189-205.; 
    PubMed
  175. Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.
    Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM
    PubMed
  176. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness.
    Le LT, Cazares O, Mouw JK, Chatterjee S, Macias H, Moran A, Ramos J, Keely PJ, Weaver VM, Hinck L
    J Cell Biol. 2016 Mar 14; 212(6):707-19.; 
    PubMed
  177. Fighting the force: Potential of homeobox genes for tumor microenvironment regulation.
    Northcott JM, Northey JJ, Barnes JM, Weaver VM
    Biochim Biophys Acta. 2015 Apr; 1855(2):248-53.; 
    PubMed
  178. The cancer glycocalyx mechanically primes integrin-mediated growth and survival.
    Paszek MJ, DuFort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver VM
    Nature. 2014 Jul 17; 511(7509):319-25.; 
    PubMed
  179. Collagen architecture in pregnancy-induced protection from breast cancer.
    Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P
    J Cell Sci. 2013 Sep 15; 126(Pt 18):4108-10.; 
    PubMed
  180. The extracellular matrix: a dynamic niche in cancer progression.
    Lu P, Weaver VM, Werb Z
    J Cell Biol. 2012 Feb 20; 196(4):395-406.; 
    PubMed
  181. Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties.
    Miroshnikova YA, Jorgens DM, Spirio L, Auer M, Sarang-Sieminski AL, Weaver VM
    Phys Biol. 2011 Apr; 8(2):026013.; 
    PubMed
  182. Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate.
    Paszek MJ, Boettiger D, Weaver VM, Hammer DA
    PLoS Comput Biol. 2009 Dec; 5(12):e1000604.; 
    PubMed
  183. Biomechanical regulation of cell orientation and fate.
    Lopez JI, Mouw JK, Weaver VM
    Oncogene. 2008 Nov 24; 27(55):6981-93.; 
    PubMed
  184. Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis.
    Kass L, Erler JT, Dembo M, Weaver VM
    Int J Biochem Cell Biol. 2007; 39(11):1987-94.; 
    PubMed
  185. Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression.
    Cowden Dahl KD, Robertson SE, Weaver VM, Simon MC
    Mol Biol Cell. 2005 Apr; 16(4):1901-12.; 
    PubMed
  186. The tissue microenvironment as an epigenetic tumor modifier.
    Unger M, Weaver VM
    Methods Mol Biol. 2003; 223:315-47.; 
    PubMed
  187. Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells.
    Weaver VM, Bissell MJ
    J Mammary Gland Biol Neoplasia. 1999 Apr; 4(2):193-201.; 
    PubMed
  188. Multicollinearity may lead to artificial interaction: an example from a cross sectional study of biomarkers.
    Sithisarankul P, Weaver VM, Diener-West M, Strickland PT
    Southeast Asian J Trop Med Public Health. 1997 Jun; 28(2):404-9.; 
    PubMed
  189. Communicable disease and firefighters.
    Weaver VM, Arndt SD
    Occup Med. 1995 Oct-Dec; 10(4):747-62.; 
    PubMed
  190. Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation.
    Sharma S, Prathigudupu V, Cable C, Serrano LR, Nerella S, Chen A, Hassan G, Lakins J, Valenzuela CL, Tsukui T, Ramamoorthi R, Kim JJ, Willenbring H, Mattis AN, Volk RF, Zaro BW, Coon JJ, Beresis R, DeGrado WF, Weaver VM, Christenson SA, Jo H, Chen JY
    Sci Transl Med. 2025 Aug 27; 17(813):eads9470.; 
    PubMed
  191. Live imaging of the extracellular matrix with a glycan-binding fluorophore.
    Fiore A, Yu G, Northey JJ, Patel R, Ravenscroft TA, Ikegami R, Kolkman W, Kumar P, Dilan TL, Ruetten VMS, Ahrens MB, Shroff H, Wang S, Weaver VM, Pedram K
    Nat Methods. 2025 May; 22(5):1070-1080.; 
    PubMed
  192. Imaging the extracellular matrix in live tissues and organisms with a glycan-binding fluorophore.
    Fiore A, Yu G, Northey JJ, Patel R, Ravenscroft TA, Ikegami R, Kolkman W, Kumar P, Grimm JB, Dilan TL, Ruetten VMS, Ahrens MB, Shroff H, Lavis LD, Wang S, Weaver VM, Pedram K
    bioRxiv. 2024 May 10.; 
    PubMed
  193. Design of a mucin-selective protease for targeted degradation of cancer-associated mucins.
    Pedram K, Shon DJ, Tender GS, Mantuano NR, Northey JJ, Metcalf KJ, Wisnovsky SP, Riley NM, Forcina GC, Malaker SA, Kuo A, George BM, Miller CL, Casey KM, Vilches-Moure JG, Ferracane MJ, Weaver VM, Läubli H, Bertozzi CR
    Nat Biotechnol. 2024 Apr; 42(4):597-607.; 
    PubMed
  194. Mechanosensitive Steroid Hormone Signaling and Cell Fate.
    Northey JJ, Weaver VM
    Endocrinology. 2022 08 01; 163(8).; 
    PubMed
  195. Tissue mechanics in stem cell fate, development, and cancer.
    Hayward MK, Muncie JM, Weaver VM
    Dev Cell. 2021 07 12; 56(13):1833-1847.; 
    PubMed
  196. Membrane Tension Locks In Pluripotency.
    Muncie JM, Weaver VM
    Cell Stem Cell. 2021 02 04; 28(2):175-176.; 
    PubMed
  197. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
    Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY
    Sci Transl Med. 2020 08 19; 12(557).; 
    PubMed
  198. Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells.
    Eliazer S, Muncie JM, Christensen J, Sun X, D'Urso RS, Weaver VM, Brack AS
    Cell Stem Cell. 2019 11 07; 25(5):654-665.e4.; 
    PubMed
  199. The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate.
    Muncie JM, Weaver VM
    Curr Top Dev Biol. 2018; 130:1-37.; 
    PubMed
  200. α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site.
    Miroshnikova YA, Rozenberg GI, Cassereau L, Pickup M, Mouw JK, Ou G, Templeman KL, Hannachi EI, Gooch KJ, Sarang-Sieminski AL, García AJ, Weaver VM
    Mol Biol Cell. 2017 Nov 01; 28(22):2958-2977.; 
    PubMed
  201. Tissue mechanics regulate brain development, homeostasis and disease.
    Barnes JM, Przybyla L, Weaver VM
    J Cell Sci. 2017 01 01; 130(1):71-82.; 
    PubMed
  202. Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions.
    Ou G, Thakar D, Tung JC, Miroshnikova YA, Dufort CC, Gutierrez E, Groisman A, Weaver VM
    Integr Biol (Camb). 2016 07 11; 8(7):795-804.; 
    PubMed
  203. Tumor-induced solid stress activates β-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells.
    Ou G, Weaver VM
    Bioessays. 2015 Dec; 37(12):1293-7.; 
    PubMed
  204. The extracellular matrix modulates the hallmarks of cancer.
    Pickup MW, Mouw JK, Weaver VM
    EMBO Rep. 2014 Dec; 15(12):1243-53.; 
    PubMed
  205. Deconstructing signaling in three dimensions.
    Rubashkin MG, Ou G, Weaver VM
    Biochemistry. 2014 Apr 08; 53(13):2078-90.; 
    PubMed
  206. MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis.
    Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ
    Dev Cell. 2013 May 28; 25(4):402-16.; 
    PubMed
  207. In situ force mapping of mammary gland transformation.
    Lopez JI, Kang I, You WK, McDonald DM, Weaver VM
    Integr Biol (Camb). 2011 Sep; 3(9):910-21.; 
    PubMed
  208. Forcing form and function: biomechanical regulation of tumor evolution.
    Yu H, Mouw JK, Weaver VM
    Trends Cell Biol. 2011 Jan; 21(1):47-56.; 
    PubMed
  209. Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension.
    Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA, Keely PJ
    Mol Biol Cell. 2009 Jul; 20(14):3224-38.; 
    PubMed
  210. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion.
    Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver VM, Chen CS, Assoian RK
    J Cell Sci. 2008 Jan 15; 121(Pt 2):226-33.; 
    PubMed
  211. The ultrastructure of MCF-10A acini.
    Underwood JM, Imbalzano KM, Weaver VM, Fischer AH, Imbalzano AN, Nickerson JA
    J Cell Physiol. 2006 Jul; 208(1):141-8.; 
    PubMed
  212. Watch thy neighbor: cancer is a communal affair.
    Weaver VM, Gilbert P
    J Cell Sci. 2004 Mar 15; 117(Pt 8):1287-90.; 
    PubMed
  213. Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins?
    Weaver VM
    Dev Cell. 2002 Jan; 2(1):6-7.; 
    PubMed
  214. Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus.
    Lelièvre SA, Weaver VM, Nickerson JA, Larabell CA, Bhaumik A, Petersen OW, Bissell MJ
    Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14711-6.; 
    PubMed
  215. Medical management of the multiple chemical sensitivity patient.
    Weaver VM
    Regul Toxicol Pharmacol. 1996 Aug; 24(1 Pt 2):S111-5.; 
    PubMed
  216. Occupational chemical exposures in an academic medical center.
    Weaver VM, McDiarmid MA, Guidera JA, Humphrey FE, Schaefer JA
    J Occup Med. 1993 Jul; 35(7):701-6.; 
    PubMed